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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Magnoflorine, Doxorubicin
Phytochemical Name Magnoflorine (PubChem CID: 73337 )
Anticancer drug Name Doxorubicin (PubChem CID: 31703 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Doxorubicin
Adverse Reactions Nausea, vomiting, diarrhoea. This was inferred cold nature anticancer drug.
Recommendations Hot: Ligusticum chuam; Angelica sinensis; Zingiber officinale; Panax ginseng; Pogostemon cablin
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 505
Ref_1
Pair Name Magnoflorine, Doxorubicin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression BCL2 hsa596
Up-regulation Expression BECN1 hsa8678
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP9 hsa842
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Phosphorylation MAPK14 hsa1432
Down-regulation Phosphorylation MTOR hsa2475
Down-regulation Phosphorylation PIK3CA hsa5290
Down-regulation Expression SQSTM1 hsa8878
Up-regulation Expression TP53 hsa7157
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
In Vivo Model 1×10⁷ MCF-7 cells suspended in 0.2 ml PBS were injected into the right flank of each mouse at a single site.
Result Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways
03. Reference
No. Title Href
1 Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. Biomed Pharmacother. 2020 Jan;121:109139. doi: 10.1016/j.biopha.2019.109139. Click
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